Rax^tm1.1Tfur
Targeted Allele Detail

Summary

• Symbol: Rax^tm1.1Tfur
• Name: retina and anterior neural fold homeobox; targeted mutation 1.1, Takahisa Furukawa
• MGI ID: MGI:5302230
• Synonyms: Rax^flox
• Gene: Rax Location: Chr18:66067710-66072160 bp, - strand Genetic Position: Chr18, 39.03 cM
• Alliance: Rax^tm1.1Tfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177908
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert flox sites upstream of exon 1 and intron 2 by homologous recombination in ES cells. An Frt-flanked PGK-neo selection cassette was inserted also, and removed after selection of correctly targeted clones by Flp recombinase. Cre-mediated recombination will result in excision of exons 1 and 2 of Rax, producing a null allele. (J:177908)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rax Mutation: 16 strains or lines available

References

• Original: J:177908 Muranishi Y, et al., An Essential Role for RAX Homeoprotein and NOTCH-HES Signaling in Otx2 Expression in Embryonic Retinal Photoreceptor Cell Fate Determination. J Neurosci. 2011 Nov 16;31(46):16792-807
• All: 4 reference(s)