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Dll4tm2.1Vlcg
Targeted Allele Detail
Summary
Symbol: Dll4tm2.1Vlcg
Name: delta like canonical Notch ligand 4; targeted mutation 2.1, Velocigene
MGI ID: MGI:5302387
Synonyms: Dll4COIN, Dll4i3COIN
Gene: Dll4  Location: Chr2:119156286-119166145 bp, + strand  Genetic Position: Chr2, 59.97 cM, cytoband E3
Alliance: Dll4tm2.1Vlcg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177797
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA conditional by inversion (COIN) intron consisting of a lox66_SA-Egpf-polyA_lox71 was inserted in the antisense orientation into intron 3 via homologous recombination, splitting intron 3 into 2 new exons (631 and 144 bp in length). The two lox sites are in reverse complementation orientation, thus cre-mediated recombination will irreversibly invert the inserted sequence. In addition, an FRT flanked hygromycin-delta-thymidine kinase cassette was inserted after the COIN intron. Flp-mediated recombination removed the hygromycin cassette. (J:177797)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dll4 Mutation:  27 strains or lines available
References
Original:  J:177797 Lobov IB, et al., The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow. Blood. 2011 Jun 16;117(24):6728-37
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory