Mc3r^tm1Butl
Targeted Allele Detail

Summary

• Symbol: Mc3r^tm1Butl
• Name: melanocortin 3 receptor; targeted mutation 1, Andrew A Butler
• MGI ID: MGI:5302394
• Synonyms: Mc3r^TB
• Gene: Mc3r Location: Chr2:172090412-172093034 bp, + strand Genetic Position: Chr2, 94.8 cM
• Alliance: Mc3r^tm1Butl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178147
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-stop-loxP cassette was inserted just upstream of the initiation codon and an IRES-AcGFP1was inserted after the open reading frame via homologous recombination. (J:178147)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc3r Mutation: 31 strains or lines available

References

• Original: J:178147 Begriche K, et al., Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis. J Biol Chem. 2011 Nov 25;286(47):40771-81
• All: 6 reference(s)