Tg(Mt1-IL6)28Gci
Transgene Detail

Summary

• Symbol: Tg(Mt1-IL6)28Gci
• Name: transgene insertion 28, Gennaro Ciliberto
• MGI ID: MGI:5302421
• Synonyms: MT-1/hIL-6
• Transgene: Tg(Mt1-IL6)28Gci Location: unknown
• Alliance: Tg(Mt1-IL6)28Gci page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-IL6)28Gci expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: This transgene consists of the human IL6 cDNA under the control of the mouse metallothionein-1 promoter. A 1.7-kb DNA fragment corresponding to the 3' portion of human beta-globin gene is also inserted downstream of the IL6 cDNA to stabilize the IL6 mRNA. Human IL6 mRNA is only detected in the liver. (J:18424)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:18424 Fattori E, et al., Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood. 1994 May 1;83(9):2570-9
• All: 5 reference(s)