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Efnb1tm1.1Jwu
Targeted Allele Detail
Summary
Symbol: Efnb1tm1.1Jwu
Name: ephrin B1; targeted mutation 1.1, Jiangping Wu
MGI ID: MGI:5302529
Synonyms: Efnb1f
Gene: Efnb1  Location: ChrX:98179736-98192597 bp, + strand  Genetic Position: ChrX, 43.22 cM, cytoband D
Alliance: Efnb1tm1.1Jwu page
Decreased thymus and spleen weight and cellularity in Efnb1tm1.1Jwu/Efnb1tm1.1Jwu Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178148
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:178148)
Generation of the Efnb1tm1.1Jwu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efnb1 Mutation:  15 strains or lines available
References
Original:  J:178148 Luo H, et al., Efnb1 and efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem. 2011 Dec 2;286(48):41135-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory