Efnb1tm1.1Jwu
Targeted Allele Detail
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Symbol: |
Efnb1tm1.1Jwu |
Name: |
ephrin B1; targeted mutation 1.1, Jiangping Wu |
MGI ID: |
MGI:5302529 |
Synonyms: |
Efnb1f |
Gene: |
Efnb1 Location: ChrX:98179736-98192597 bp, + strand Genetic Position: ChrX, 43.22 cM, cytoband D
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Alliance: |
Efnb1tm1.1Jwu page
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Decreased thymus and spleen weight and cellularity in Efnb1tm1.1Jwu/Efnb1tm1.1Jwu Efnb2tm1.1Jwu/Efnb2tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:178148
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed.
(J:178148)
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Generation of the Efnb1tm1.1Jwu allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Efnb1 Mutation: |
15 strains or lines available
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Original: |
J:178148 Luo H, et al., Efnb1 and efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem. 2011 Dec 2;286(48):41135-52 |
All: |
4 reference(s) |
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