Efnb2^tm1.1Jwu
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1.1Jwu
• Name: ephrin B2; targeted mutation 1.1, Jiangping Wu
• MGI ID: MGI:5302530
• Synonyms: Efnb2^f
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1.1Jwu page

Decreased thymus and spleen weight and cellularity in Efnb1^tm1.1Jwu/Efnb1^tm1.1Jwu Efnb2^tm1.1Jwu/Efnb2^tm1.1Jwu Tg(Lck-cre)I540Jxm/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178148
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:178148)

Generation of the Efnb2^tm1.1Jwu allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 29 strains or lines available

References

• Original: J:178148 Luo H, et al., Efnb1 and efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem. 2011 Dec 2;286(48):41135-52
• All: 6 reference(s)