Mecp2^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1.1Meg
• Name: methyl CpG binding protein 2; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5302542
• Synonyms: MeCP2 S421A
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178533
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of a modified exon in which nucleotide substitution (A to C) results in the amino acid substitution of alanine for serine at position 421 (S421A). Cre-mediated recombination removed the neo cassette. (J:178533)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 41 strains or lines available

References

• Original: J:178533 Cohen S, et al., Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron. 2011 Oct 6;72(1):72-85
• All: 6 reference(s)