Del(17D17Jcs40-D17Mit198)7Jcs
Radiation induced Allele Detail

Summary

• Symbol: Del(17D17Jcs40-D17Mit198)7Jcs
• Name: deletion, Chr 17, John C Schimenti 7
• MGI ID: MGI:5303073
• Synonyms: D17Nkx2.5^df4J
• Gene: Del(17D17Jcs40-D17Mit198)7Jcs Location: Chr17:25147260-27878219 bp Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86784
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Radiation induced (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(17D17Jcs40-D17Mit198)7Jcs involves 138 genes/genome features (Gm25083, Gm26694, Gm22420 ...) View all
• Mutation details: A beta-Actin-Neo and HSC-tk sequence was inserted into the BglII site in the last exon of the Nkx2-5 gene in v6.5 ES cells. A population of properly targeted ES cells was exposed to 4Gy of radiation from a Cesium- 137 source. Deletion mutants were selected in ES cells by restoration of "tk" sensitivity. Four mouse stocks and 11 mutated ES cell lines were established. (J:86784, J:99488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(17D17Jcs40-D17Mit198)7Jcs Mutation: 0 strains or lines available

References

• Original: J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
• All: 3 reference(s)