Ccne1^tm2.1Pisc
Targeted Allele Detail

Summary

• Symbol: Ccne1^tm2.1Pisc
• Name: cyclin E1; targeted mutation 2.1, Piotr Sicinski
• MGI ID: MGI:5304316
• Synonyms: Cyclin E1^Ntag
• Gene: Ccne1 Location: Chr7:37797409-37806915 bp, - strand Genetic Position: Chr7, 25.35 cM
• Alliance: Ccne1^tm2.1Pisc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178882
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace the start codon of the cyclin E1 (Ccne1) gene with a Flag-HA tag. A loxP-flanked hygromycin (hyg) selection cassette was inserted downstream of exon 3. Cre-mediated recombination removed the hygro cassette. (J:178882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccne1 Mutation: 23 strains or lines available

References

• Original: J:178882 Odajima J, et al., Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68
• All: 1 reference(s)