Is(14)5Rdf
Targeted Allele Detail

Summary

• Symbol: Is(14)5Rdf
• Name: insertion, Chr 14, Riccardo Dalla-Favera 5
• MGI ID: MGI:5304347
• Synonyms: Is5Rdf
• Gene: Is(14)5Rdf Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179879
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting vector contained a PGK-Hygro cassette, loxP and FRT sites, inserted in the telomeric region of 14qC3, approximately 2 kb centromeric to the last exon of Rnaseh2b gene.

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Is(14)5Rdf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Is(14)5Rdf Mutation: 1 strain or line available

Notes

This allele was originally generated in cis with Is(14)1Rdf.

References

• Original: J:179879 Lia M, et al., Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines. Blood. 2012 Mar 29;119(13):2981-90
• All: 1 reference(s)