Insc^tm1Jakn
Targeted Allele Detail

Summary

• Symbol: Insc^tm1Jakn
• Name: INSC spindle orientation adaptor protein; targeted mutation 1, Juergen A Knoblich
• MGI ID: MGI:5304348
• Synonyms: mInsc^loxP
• Gene: Insc Location: Chr7:114342931-114449615 bp, + strand Genetic Position: Chr7, 60.23 cM
• Alliance: Insc^tm1Jakn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked IRES-GFP and neo cassette were inserted downstream of exon 3 via homologous recombination. (J:178712)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insc Mutation: 30 strains or lines available

References

• Original: J:178712 Postiglione MP, et al., Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron. 2011 Oct 20;72(2):269-84
• All: 2 reference(s)