Trpv5^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Trpv5^m1Btlr
• Name: transient receptor potential cation channel, subfamily V, member 5; mutation 1, Bruce Beutler
• MGI ID: MGI:5304494
• Synonyms: gingame
• Gene: Trpv5 Location: Chr6:41629107-41657703 bp, - strand Genetic Position: Chr6, 19.83 cM
• Alliance: Trpv5^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The gingame phenotype was identified among ENU-mutagenized G3 mice in a screen for mutants with susceptibility to dextran sulfate sodium (DSS)-induced colitis. ENU-induced A to T transition at position 416037032 bp in the Genbank genomic region NC_000072.5 on Chr6:41602769-41630722 bp, - strand. The mutation corresponds to nucleotide 1031 in exon 8 of 15 total exons. The mutation results in a valine to glutamic acid substitution at amino acid 306. (J:192586)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpv5 Mutation: 49 strains or lines available

References

• Original: J:192586 Tomisato W, et al., Mutagenetix entry for gingame. MGI Direct Data Submission. 2013;(Feb 20)
• All: 1 reference(s)