Del(14Trim13-Rnaseh2b)6Rdf
Targeted Allele Detail

Summary

• Symbol: Del(14Trim13-Rnaseh2b)6Rdf
• Name: deletion, Chr 14, Riccardo Dalla-Favera 6
• MGI ID: MGI:5304666
• Synonyms: CDR^-, Del6Rdf
• Gene: Del(14Trim13-Rnaseh2b)6Rdf Location: Chr14:61835696-62610441 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179879
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(14Trim13-Rnaseh2b)6Rdf involves 16 genes/genome features (Gm27845, Gm27747, Gm27928 ...) View all
• Mutation details: Flp-mediated recombination removed the 800 kb region between Trim13 and Rnaseh2b flanked by Is(14)1Rdf and Is(14)5Rdf, respectively, as well as the EGFP. This deletion removes Trim13, Kcnrg, Dleu2, Gm20034, Mir16-1, Mir15a, Mir1196, Dleu7, and Rnaseh2b. (J:179879)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Del(14Trim13-Rnaseh2b)6Rdf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(14Trim13-Rnaseh2b)6Rdf Mutation: 0 strains or lines available

References

• Original: J:179879 Lia M, et al., Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines. Blood. 2012 Mar 29;119(13):2981-90
• All: 1 reference(s)