Thratm1.1Fcas
Targeted Allele Detail
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Symbol: |
Thratm1.1Fcas |
Name: |
thyroid hormone receptor alpha; targeted mutation 1.1, Francois Casas |
MGI ID: |
MGI:5304668 |
Synonyms: |
p43- |
Gene: |
Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
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Alliance: |
Thratm1.1Fcas page
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Germline Transmission: |
Earliest citation of germline transmission:
J:179839
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 3 was replaced with one in which a nucleotide substitution produced the amino acid substitution of leucine for methionine at position 109 (M109L). The floxed neo cassette inserted downstream of exon 4 was removed by cre-mediated recombination. Western blot analysis on quadriceps muscle extracts confirmed the absence of protein expression.
(J:179839)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Thra Mutation: |
40 strains or lines available
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Original: |
J:179839 Blanchet E, et al., Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J. 2012 Jan;26(1):40-50 |
All: |
8 reference(s) |
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