Igh-J^{tm1(CB20)Riho}
Targeted Allele Detail

Summary

• Symbol: Igh-J^{tm1(CB20)Riho}
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Rikard Holmdahl
• MGI ID: MGI:5304723
• Synonyms: ABC^-
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion
• Mutation details: The Igh-J region was replaced with a prearranged VDJ segment CB20 (a germline-encoded anti-C1 antibody). A floxed neo cassette was removed by cre-mediated recombination. (J:179456)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:179456 Cao D, et al., Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II. J Immunol. 2011 Nov 1;187(9):4451-8
• All: 1 reference(s)