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Ppm1atm1Xya
Targeted Allele Detail
Summary
Symbol: Ppm1atm1Xya
Name: protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1, Xiao Yang
MGI ID: MGI:5304768
Synonyms: Ppm1afl
Gene: Ppm1a  Location: Chr12:72804231-72846593 bp, + strand  Genetic Position: Chr12, 30.26 cM, cytoband C3
Alliance: Ppm1atm1Xya page
Delayed re-epithelialization during wound healing in Ppm1atm1Xya/Ppm1atm1Xya Tg(KRT5-cre)1Xya/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178733
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. (J:178733)
Generation of the Ppm1atm1Xya and Ppm1atm1.1Xya alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppm1a Mutation:  23 strains or lines available
References
Original:  J:178733 Yang X, et al., Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2. J Biol Chem. 2011 Dec 9;286(49):42267-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory