Ppm1a^tm1.1Xya
Targeted Allele Detail

Summary

• Symbol: Ppm1a^tm1.1Xya
• Name: protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1.1, Xiao Yang
• MGI ID: MGI:5304773
• Gene: Ppm1a Location: Chr12:72804231-72846593 bp, + strand Genetic Position: Chr12, 30.26 cM, cytoband C3
• Alliance: Ppm1a^tm1.1Xya page

Delayed re-epithelialization during wound healing in Ppm1a^tm1.1Xya/Ppm1a^tm1.1Xya mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178733
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Ppm1a^tm1Xya removed exons 2 and 3. RT-PCR confirmed the absence of transcript expression in the liver, stomach, and skin. (J:178733)

Generation of the Ppm1a^tm1Xya and Ppm1a^tm1.1Xya alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppm1a Mutation: 23 strains or lines available

References

• Original: J:178733 Yang X, et al., Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2. J Biol Chem. 2011 Dec 9;286(49):42267-73
• All: 1 reference(s)