Myd88^tm1.1Papr
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1.1Papr
• Name: myeloid differentiation primary response gene 88; targeted mutation 1.1, Rajita Pappu
• MGI ID: MGI:5304811
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1.1Papr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178967
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 2 through 5 and the FRT-flanked neo cassette. RT-PCR on epidermal keratinocyte extracts confirmed the absence of transcript expression. (J:178967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 52 strains or lines available

References

• Original: J:178967 Ramirez-Carrozzi V, et al., IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 2011 Dec;12(12):1159-66
• All: 1 reference(s)