Ptpn2^tm1.1Ttig
Targeted Allele Detail

Summary

• Symbol: Ptpn2^tm1.1Ttig
• Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1.1, Tony Tiganis
• MGI ID: MGI:5304815
• Synonyms: Ptpn2^fl, Ptpn2^lox
• Gene: Ptpn2 Location: Chr18:67798581-67857665 bp, - strand Genetic Position: Chr18, 40.06 cM
• Alliance: Ptpn2^tm1.1Ttig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179621
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 5 and 6 floxed. (J:179621)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn2 Mutation: 44 strains or lines available

References

• Original: J:179621 Loh K, et al., Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011 Nov 2;14(5):684-99
• All: 18 reference(s)