Spint1^tm2.1Hk
Targeted Allele Detail

Summary

• Symbol: Spint1^tm2.1Hk
• Name: serine protease inhibitor, Kunitz type 1; targeted mutation 2.1, Hiroaki Kataoka
• MGI ID: MGI:5304850
• Synonyms: Spint1^LoxP
• Gene: Spint1 Location: Chr2:119067841-119079995 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E5
• Alliance: Spint1^tm2.1Hk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179937
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neo cassette was inserted downstream of exon 11. Cre-mediated recombination removed the neo cassette and left exons 4 through 11 floxed. (J:179937)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spint1 Mutation: 26 strains or lines available

References

• Original: J:179937 Kawaguchi M, et al., Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity. Am J Pathol. 2011 Oct;179(4):1815-26
• All: 4 reference(s)