Slc14a2^tm1Bxy
Targeted Allele Detail

Summary

• Symbol: Slc14a2^tm1Bxy
• Name: solute carrier family 14 (urea transporter), member 2; targeted mutation 1, Baoxue Yang
• MGI ID: MGI:5304854
• Synonyms: UT-A2^-
• Gene: Slc14a2 Location: Chr18:78189363-78640157 bp, - strand Genetic Position: Chr18, 52.53 cM
• Alliance: Slc14a2^tm1Bxy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179936
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The isoform UT-A2 promoter between exon 13 and 14 was replaced with a hygro cassette. Northern blot analysis on kidney extracts confirmed the the absence of isoform A2 protein expression. (J:179936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc14a2 Mutation: 53 strains or lines available

Notes

This allele was originally generated in ES cells containing Slc14a1^tm1Ask.

References

• Original: J:179936 Lei T, et al., Role of thin descending limb urea transport in renal urea handling and the urine concentrating mechanism. Am J Physiol Renal Physiol. 2011 Dec;301(6):F1251-9
• All: 1 reference(s)