Gak^tm1Noj
Targeted Allele Detail

Summary

• Symbol: Gak^tm1Noj
• Name: cyclin G associated kinase; targeted mutation 1, Hiroshi Nojima
• MGI ID: MGI:5305045
• Synonyms: GAK-kd
• Gene: Gak Location: Chr5:108717277-108777621 bp, - strand Genetic Position: Chr5, 53.2 cM
• Alliance: Gak^tm1Noj page

Lung tissue defects in Gak^tm1Noj/Gak^tm1Noj pups

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 - 4, encoding the kinase domain, were replaced with a pgk-neo cassette via homologous recombination. (J:179585)

Generation of the Gak^tm1Noj allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gak Mutation: 60 strains or lines available

References

• Original: J:179585 Tabara H, et al., Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction. PLoS One. 2011;6(10):e26034
• All: 1 reference(s)