Rr7^tm3.1Kio
Targeted Allele Detail

Summary

• Symbol: Rr7^tm3.1Kio
• Name: regulatory region 7; targeted mutation 3.1, Dimitris Kioussis
• MGI ID: MGI:5305062
• Synonyms: CD8/lxLCRlx
• Gene: Rr7 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr7^tm3.1Kio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179326
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Insertion
• Mutation details: A loxP site flanked neomycin resistance gene cassette with a 5' loxP site and floxed human CD2 locus control region were inserted between the DNase I hypersensitivity clusters cII and cIII of the CD8 locus control region. Cre-mediated recombination removed the neo cassette. (J:179326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr7 Mutation: 0 strains or lines available

References

• Original: J:179326 Menzel U, et al., Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences. J Immunol. 2011 Oct 1;187(7):3712-20
• All: 1 reference(s)