Ror2^Y324C
Chemically induced Allele Detail

Summary

• Symbol: Ror2^Y324C
• Name: receptor tyrosine kinase-like orphan receptor 2; Tyr324Cys
• MGI ID: MGI:5305088
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^Y324C page

Ror2^Y324C/Ror2^Y324C and Ror2^tm1Ymi/Ror2^tm1Ymi mice exhibit short tails at E10.75

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU induced an A-to-G mutation in exon 7 (c.971A>G) causing a tyrosine to cysteine substitution at position 324 (p.Y324C). This missense mutation falls in the kringle domain of the encoded peptide. The mutant protein is stably expressed. (J:98216, J:179805)

Schematic of the Ror2^Y324C ENU allele

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ror2^Y324C/Ror2^Y324C	involves: C57BL/6J
cx2	Bax^tm1Sjk/Bax^tm1Sjk Ror2^Y324C/Ror2^Y324C	involves: 129X1/SvJ * C57BL/6J

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
cellular	√	√
abnormal primordial germ cell morphology		√
decreased primordial germ cell number	√	√
increased primordial germ cell apoptosis	√
abnormal primordial germ cell migration	√	√
digestive/alimentary system	√
abnormal hindgut morphology	√
embryo	√
impaired somite development	√
limbs/digits/tail	√
abnormal tail development	√
mortality/aging	√
perinatal lethality	√
reproductive system	√	√
abnormal primordial germ cell morphology		√
decreased primordial germ cell number	√	√
abnormal reproductive system physiology	√
increased primordial germ cell apoptosis	√
abnormal primordial germ cell migration	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 126 strains or lines available

References

• Original: J:179805 Laird DJ, et al., Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec;7(12):e1002428
• All: 4 reference(s)