Ror2^Y324C
Chemically induced Allele Detail

Summary

• Symbol: Ror2^Y324C
• Name: receptor tyrosine kinase-like orphan receptor 2; Tyr324Cys
• MGI ID: MGI:5305088
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^Y324C page

Ror2^Y324C/Ror2^Y324C and Ror2^tm1Ymi/Ror2^tm1Ymi mice exhibit short tails at E10.75

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU induced an A-to-G mutation in exon 7 (c.971A>G) causing a tyrosine to cysteine substitution at position 324 (p.Y324C). This missense mutation falls in the kringle domain of the encoded peptide. The mutant protein is stably expressed. (J:98216, J:179805)

Schematic of the Ror2^Y324C ENU allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:179805 Laird DJ, et al., Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec;7(12):e1002428
• All: 4 reference(s)