Smad2^tm1Xya
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1Xya
• Name: SMAD family member 2; targeted mutation 1, Xiao Yang
• MGI ID: MGI:5305134
• Synonyms: Smad2^fl
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1Xya page

Accelerated re-epithelialization during wound healing in Smad2^tm1Xya/Smad2^tm1Xya Tg(KRT5-cre)1Xya/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180045
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 12. (J:180045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:180045 Zhou J, et al., Establishment of Smad2 conditional gene targeting mice based on the Cre-LoxP system. Sci China C Life Sci. 2002 Apr;45(2):129-37
• All: 2 reference(s)