Nlrp12^tm1Tdk
Targeted Allele Detail

Summary

• Symbol: Nlrp12^tm1Tdk
• Name: NLR family, pyrin domain containing 12; targeted mutation 1, Thirumala-Devi Kanneganti
• MGI ID: MGI:5305143
• Gene: Nlrp12 Location: Chr7:3267458-3298370 bp, - strand Genetic Position: Chr7, 1.88 cM
• Alliance: Nlrp12^tm1Tdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neo cassette via homologous recombination. (J:178951)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nlrp12^tm1Tdk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp12 Mutation: 51 strains or lines available

References

• Original: J:178951 Zaki MH, et al., The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis. Cancer Cell. 2011 Nov 15;20(5):649-60
• All: 7 reference(s)