Sirt1^tm1.2Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt1^tm1.2Cxd
• Name: sirtuin 1; targeted mutation 1.2, Chu-Xia Deng
• MGI ID: MGI:5305225
• Synonyms: Sirt1^flox5-6
• Gene: Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Sirt1^tm1.2Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179193
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette leaving exons 5 and 6 flanked by loxP sites. Liver specific deletion of the two floxed exons eliminates protein product in the liver. (J:140089, J:179193)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt1 Mutation: 81 strains or lines available

References

• Original: J:179193 Wang RH, et al., Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6(7):682-90
• All: 4 reference(s)