Ncor1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Ncor1^tm1.1Ics
• Name: nuclear receptor co-repressor 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5305235
• Synonyms: NCoR1^L2
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178827
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11 and a loxP and FRT flanked neo cassette was inserted downstream of exon 11 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 11 floxed. (J:178827)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 396 strains or lines available

References

• Original: J:178827 Yamamoto H, et al., NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 2011 Nov 11;147(4):827-39
• All: 24 reference(s)