Pbx1^tm1Koss
Targeted Allele Detail

Summary

• Symbol: Pbx1^tm1Koss
• Name: pre B cell leukemia homeobox 1; targeted mutation 1, Matthew J Koss
• MGI ID: MGI:5305253
• Synonyms: Pbx1^f, Pbx1^flox
• Gene: Pbx1 Location: Chr1:167946933-168259839 bp, - strand Genetic Position: Chr1, 75.95 cM
• Alliance: Pbx1^tm1Koss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178316
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. (J:184521)

Expression

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pbx1 Mutation: 40 strains or lines available

References

• Original: J:178316 Ferretti E, et al., A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell. 2011 Oct 18;21(4):627-41
• All: 11 reference(s)