Sftpc^{tm1(cre/ERT2)Blh}
Targeted Allele Detail

Summary

• Symbol: Sftpc^{tm1(cre/ERT2)Blh}
• Name: surfactant associated protein C; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:5305340
• Synonyms: Sftp-CreER
• Gene: Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Sftpc^{tm1(cre/ERT2)Blh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180047
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sftpc^{tm1(cre/ERT2)Blh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sftpc (MGI:109517)

• Mutation details: An IRES-creERT cassette, together with an FRT flanked PGK-neo cassette, were inserted into the 3' UTR. The neo selection cassette was subsequently excised by crossing to mice expressing flp recombinase. (J:180047, J:182218)

Schematic of Sftpc^{tm1(cre/ERT2)Blh} (Sftpc-CreER) allele.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sftpc (mouse) Summary of all recombinase alleles driven by Sftpc. Alliance mouse Sftpc gene page

Tumor Data

List all tumor models in MMHCdb carrying Sftpc^{tm1(cre/ERT2)Blh}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sftpc Mutation: 24 strains or lines available

References

• Original: J:180047 Rock JR, et al., Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):E1475-83
• All: 89 reference(s)