Thtm1.1Ich
Targeted Allele Detail
|
Symbol: |
Thtm1.1Ich |
Name: |
tyrosine hydroxylase; targeted mutation 1.1, Hiroshi Ichinose |
MGI ID: |
MGI:5305343 |
Synonyms: |
Thfl |
Gene: |
Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
|
Alliance: |
Thtm1.1Ich page
|
|
Dopamine distribution is reduced in the Thtm1.1Ich/Thtm1.1Ich striatum
Show the 1 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:178698
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Conditional ready, No functional change) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 9. Cre-mediated recombination removed the neo cassette and left exons 6 through 9 floxed.
(J:178698)
|
|
Generation of the Thtm1.1Ich allele |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Th Mutation: |
58 strains or lines available
|
|
Original: |
J:178698 Tokuoka H, et al., Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem. 2011 Dec 16;286(50):43549-58 |
All: |
3 reference(s) |
|