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Thtm1.1Ich
Targeted Allele Detail
Summary
Symbol: Thtm1.1Ich
Name: tyrosine hydroxylase; targeted mutation 1.1, Hiroshi Ichinose
MGI ID: MGI:5305343
Synonyms: Thfl
Gene: Th  Location: Chr7:142446516-142453732 bp, - strand  Genetic Position: Chr7, 88.06 cM
Alliance: Thtm1.1Ich page
Dopamine distribution is reduced in the Thtm1.1Ich/Thtm1.1Ich striatum

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178698
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 9. Cre-mediated recombination removed the neo cassette and left exons 6 through 9 floxed. (J:178698)
Generation of the Thtm1.1Ich allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Th Mutation:  58 strains or lines available
References
Original:  J:178698 Tokuoka H, et al., Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem. 2011 Dec 16;286(50):43549-58
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory