Igh^tm1Ktom
Targeted Allele Detail

Summary

• Symbol: Igh^tm1Ktom
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Kazuma Tomizuka
• MGI ID: MGI:5305473
• Synonyms: deltaH^-
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• A neo cassette replaced a 3.7 kb segment containing the Cmu2, Cmu3-4, and Mmu1-2. (J:59894)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:59894 Tomizuka K, et al., Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):722-7
• All: 2 reference(s)