Igk^tm1Ktom
Targeted Allele Detail

Summary

• Symbol: Igk^tm1Ktom
• Name: immunoglobulin kappa chain complex; targeted mutation 1, Kazuma Tomizuka
• MGI ID: MGI:5305476
• Synonyms: deltakappa^-
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59894
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neo cassette replaced a 2 kb segment containing the Ckappa exon. (J:59894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:59894 Tomizuka K, et al., Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):722-7
• All: 1 reference(s)