Tc(HSA14)SC20Ktom
Allele Detail

Summary

• Symbol: Tc(HSA14)SC20Ktom
• Name: transchromosomal, human 14, line SC20, Kazuma Tomizuka
• MGI ID: MGI:5305481
• Synonyms: hCF(SC20), Tc(SC20)
• Gene: Tc(HSA14)SC20Ktom Location: unknown
• Alliance: Tc(HSA14)SC20Ktom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59894
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Not Applicable
• Mutation: Insertion
• Tc(HSA14)SC20Ktom expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  human	IGH (3492)

• Mutation details: One-fifth of the human chromosome 14, which contains the IGH locus, was transferred into mouse embryonic stem cells via microcell-mediated chromosome transfer. Line SC20 was established. (J:59894)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tc(HSA14)SC20Ktom Mutation: 0 strains or lines available

References

• Original: J:59894 Tomizuka K, et al., Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):722-7
• All: 2 reference(s)