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Foxo1tm1.1Dac
Targeted Allele Detail
Summary
Symbol: Foxo1tm1.1Dac
Name: forkhead box O1; targeted mutation 1.1, Domenico Accili
MGI ID: MGI:5305498
Synonyms: Foxo1KQ
Gene: Foxo1  Location: Chr3:52175758-52257530 bp, + strand  Genetic Position: Chr3, 23.19 cM
Alliance: Foxo1tm1.1Dac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179687
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 2 was replaced with a floxed neo cassette and a modified exon 2 with nucleotide substitutions that result in the amino acid substitutions of glutamine for lysine at positions 219, 242, 245, 259, 262, 271, 291 (K219Q, K242Q, K245Q, K259Q, K262Q, K271Q, and K291Q). These mutations produce a constitutively acetylated allele. Cre-mediated recombination removed the neo cassette. (J:179687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:  32 strains or lines available
References
Original:  J:179687 Banks AS, et al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory