Foxo1tm1.1Dac
Targeted Allele Detail
|
Symbol: |
Foxo1tm1.1Dac |
Name: |
forkhead box O1; targeted mutation 1.1, Domenico Accili |
MGI ID: |
MGI:5305498 |
Synonyms: |
Foxo1KQ |
Gene: |
Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
|
Alliance: |
Foxo1tm1.1Dac page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:179687
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Not Applicable) |
Mutations: |
|
Insertion, Nucleotide substitutions
|
|
|
Mutation details: Exon 2 was replaced with a floxed neo cassette and a modified exon 2 with nucleotide substitutions that result in the amino acid substitutions of glutamine for lysine at positions 219, 242, 245, 259, 262, 271, 291 (K219Q, K242Q, K245Q, K259Q, K262Q, K271Q, and K291Q). These mutations produce a constitutively acetylated allele. Cre-mediated recombination removed the neo cassette.
(J:179687)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Foxo1 Mutation: |
32 strains or lines available
|
|
Original: |
J:179687 Banks AS, et al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97 |
All: |
1 reference(s) |
|