Foxo1^tm2.1Dac
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm2.1Dac
• Name: forkhead box O1; targeted mutation 2.1, Domenico Accili
• MGI ID: MGI:5305499
• Synonyms: Foxo1^KR
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm2.1Dac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with a floxed neo cassette and a modified exon 2 with nucleotide substitutions that result in the amino acid substitutions of arginine for lysine at positions 219, 242, 245, 259, 262, 271, 291 (K219R, K242R, K245R, K259R, K262R, K271R, and K291R). These mutations produce a constitutively deacetylated allele. Cre-mediated recombination removed the neo cassette. (J:179687)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 32 strains or lines available

References

• Original: J:179687 Banks AS, et al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97
• All: 5 reference(s)