Arhgef6^tm1Kkut
Targeted Allele Detail

Summary

• Symbol: Arhgef6^tm1Kkut
• Name: Rac/Cdc42 guanine nucleotide exchange factor 6; targeted mutation 1, Kerstin Kutsche
• MGI ID: MGI:5305716
• Synonyms: alphaPix/Arhgef6^-
• Gene: Arhgef6 Location: ChrX:56276845-56384089 bp, - strand Genetic Position: ChrX, 31.26 cM
• Alliance: Arhgef6^tm1Kkut page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179026
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 246 bp of intron 1, exon 1, exon 2, and intron 2 was replaced with a tau-lacZ and floxed neo cassette. Western blot analysis confirmed the absence of protein expression in the hippocampus, cortex, and cerebellum. (J:179026)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arhgef6 Mutation: 23 strains or lines available

References

• Original: J:179026 Ramakers GJ, et al., Dysregulation of Rho GTPases in the alphaPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Hum Mol Genet. 2012 Jan 15;21(2):268-86
• All: 1 reference(s)