Apc^tm1.1Alew
Targeted Allele Detail

Summary

• Symbol: Apc^tm1.1Alew
• Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Anabelle Lewis
• MGI ID: MGI:5305725
• Synonyms: APC^1322T
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1.1Alew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced the sequence corresponding to amino acids 1323 to 2845 and resulted in the deletion of all but one 20AAR domain with a truncation of the produced protein at 1322 (1322T). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 15. (J:180275)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1.1Alew

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:180275 Pollard P, et al., The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13
• All: 9 reference(s)