Apc^tm2.1Alew
Targeted Allele Detail

Summary

• Symbol: Apc^tm2.1Alew
• Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Anabelle Lewis
• MGI ID: MGI:5305728
• Synonyms: APC^deltaSAMP
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm2.1Alew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 15 was replaced with a modified one in which sequence corresponding to amino acids 1322 to 2006 was deleted. This deletion corresponds to the SAMP repeats. Cre-mediated recombination removed the neo cassette inserted downstream of the modified exon 15. (J:180057)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm2.1Alew

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:180057 Lewis A, et al., The C-terminus of Apc does not influence intestinal adenoma development or progression. J Pathol. 2012 Jan;226(1):73-83
• All: 2 reference(s)