Del(2Lnp)48Ddu
Targeted Allele Detail
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| Symbol: |
Del(2Lnp)48Ddu |
| Name: |
deletion, Chr 2, Denis Duboule 48 |
| MGI ID: |
MGI:5305744 |
| Synonyms: |
Del(rel1-rel5) |
| Gene: |
Del(2Lnp)48Ddu Location: unknown Genetic Position: Chr2, Syntenic
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| Germline Transmission: |
Earliest citation of germline transmission:
J:178930
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion
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Del(2Lnp)48Ddu involves 1 genes/genome features (Lnpk)
View all
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Mutation details: A 240 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Tg(Hoxd9/lacZ/neo)3Ddu . This region includes the global control region (GCR) and Prox enhancer region that modify expression of the Hoxd genes in the digits. At E12.5 mRNA expression of Hoxd13 was reduced to 60% of wild-type in the developing autopod. Expression of Evx2, Hoxd12, and Hoxd11 was also affected.
(J:178930)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Del(2Lnp)48Ddu Mutation: |
0 strains or lines available
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| Original: |
J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45 |
| All: |
2 reference(s) |
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Analysis Tools
