Del(2)49Ddu
Targeted Allele Detail
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| Symbol: |
Del(2)49Ddu |
| Name: |
deletion, Chr 2, Denis Duboule 49 |
| MGI ID: |
MGI:5305746 |
| Synonyms: |
Del(rel5-SB) |
| Gene: |
Del(2)49Ddu Location: unknown Genetic Position: Chr2, Syntenic
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| Germline Transmission: |
Earliest citation of germline transmission:
J:178930
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion
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Mutation details: A 300 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Tn(sb-SBlac)C.176599bFsp . The deletion encompasses the proximal half of the gene desert upstream of Lnp and does not include the global control region (GCR) that modifies expression of the Hoxd genes. At E12.5 mRNA expression of Hoxd13 and Hoxd12 was reduced to 70% of wild-type in the developing autopod.
(J:178930)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Del(2)49Ddu Mutation: |
0 strains or lines available
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| Original: |
J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45 |
| All: |
3 reference(s) |
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Analysis Tools
