Del(2Atf2)50Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Atf2)50Ddu
• Name: deletion, Chr 2, Denis Duboule 50
• MGI ID: MGI:5305748
• Synonyms: Del(SB-Atf2), HoxD^{Del(TpSB1-Atf2)}
• Gene: Del(2Atf2)50Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Del(2Atf2)50Ddu involves 2 genes/genome features (Atf2, Atp5mc3) View all
• Mutation details: A 290 kb deletion was induced by cre mediated recombination between Tn(sb-SBlac)C.176599bFsp and Atf2^tm3Nicj . The deletion encompasses the distal half of the gene desert upstream of Lnp, Atp5g3 and part of Atf2. At E12.5 mRNA expression of Hoxd10, Hoxd11, Hoxd12, and Hoxd13 is absent in the anterior part of the limb bud. Expression levels of Lnp, Evx2, and the rest of the Hoxd genes are about half of wild-type levels in the developing the limb bud. (J:178930, J:192248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Atf2)50Ddu Mutation: 0 strains or lines available

References

• Original: J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
• All: 4 reference(s)