Del(2Evx2)51Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Evx2)51Ddu
• Name: deletion, Chr 2, Denis Duboule 51
• MGI ID: MGI:5305750
• Synonyms: Del(Nsi-SB)
• Gene: Del(2Evx2)51Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Del(2Evx2)51Ddu involves 11 genes/genome features (Gm31472, Gm28640, Gm13667 ...) View all
• Mutation details: A 550 kb deletion was induced by cre mediated recombination between Evx2/Hoxd13^{tm5.1(Hoxd11/lacZ)Ddu} and Tn(sb-SBlac)C.176599bFsp . The deletion encompasses from just upstream of HoxD13 to the proximal half of the gene desert upstream of Lnp. At E12.5 mRNA expression of Hoxd13 is reduced to about one third wild-type level in the distal limbs. The deletion region includes the global control region (GCR), Prox regulatory element and regulatory islands III-V. (J:178930, J:192248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Evx2)51Ddu Mutation: 0 strains or lines available

References

• Original: J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
• All: 2 reference(s)