Del(2Atf2)52Ddu
Targeted Allele Detail
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| Symbol: |
Del(2Atf2)52Ddu |
| Name: |
deletion, Chr 2, Denis Duboule 52 |
| MGI ID: |
MGI:5305752 |
| Synonyms: |
Del(rel5-Atf2) |
| Gene: |
Del(2Atf2)52Ddu Location: unknown Genetic Position: Chr2, Syntenic
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| Germline Transmission: |
Earliest citation of germline transmission:
J:178930
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intergenic deletion
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Del(2Atf2)52Ddu involves 2 genes/genome features (Atf2, Atp5mc3)
View all
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Mutation details: A 590 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Atf2tm3Nicj . The deletion encompasses the entire gene desert upstream of Lnp and part of Atf2. At E12.5 mRNA expression levels of Lnp, Evx2, Hoxd13, Hoxd12, Hoxd11, and Hoxd10 are reduced to about 20% of wild-type levels in the developing digits.
(J:178930, J:192248)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Del(2Atf2)52Ddu Mutation: |
0 strains or lines available
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| Original: |
J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45 |
| All: |
2 reference(s) |
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Analysis Tools
