Del(2Evx2-Atf2)53Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Evx2-Atf2)53Ddu
• Name: deletion, Chr 2, Denis Duboule 53
• MGI ID: MGI:5305754
• Synonyms: Del(Nsi-Atf2)
• Gene: Del(2Evx2-Atf2)53Ddu Location: Chr2:73646853-74489901 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(2Evx2-Atf2)53Ddu involves 18 genes/genome features (Gm27421, Atf2, Gm10822 ...) View all
• Mutation details: An 830 kb deletion was induced by cre mediated recombination between Evx2/Hoxd13^{tm5.1(Hoxd11/lacZ)Ddu} and Atf2^tm3Nicj . The deletion encompasses from just upstream of HoxD13 to Atf2. Expression of Hoxd10, Hoxd11, Hoxd12, and Hoxd13 is fully abrogated in the distal region of the developing autopod. The deletion region includes the global control region (GCR), Prox regulatory element and regulatory islands I-II and III-V. (J:178930, J:192248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Evx2-Atf2)53Ddu Mutation: 0 strains or lines available

References

• Original: J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
• All: 6 reference(s)