Dp(16Tiam1-Kcnj6)6Yey
Targeted Allele Detail

Summary

• Symbol: Dp(16Tiam1-Kcnj6)6Yey
• Name: duplication, Chr 16, Y Eugene Yu 6
• MGI ID: MGI:5305765
• Synonyms: Dp(16)2Yey
• Gene: Dp(16Tiam1-Kcnj6)6Yey Location: Chr16:89583999-94798555 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180201
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Dp(16Tiam1-Kcnj6)6Yey involves 110 genes/genome features (Gm22933, Gm22344, Gm22745 ...) View all
• Mutation details: ES cells were targeted twice with MICER vectors inserting 403 kb upstream of the Tiam1 gene and 155 kb downstream of Kcnj6. Transient transfection using a cre-expression vector resulted in recombination between the two targeted sites creating a duplication/deficiency allele pair. (J:180201)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Tiam1-Kcnj6)6Yey Mutation: 2 strains or lines available

References

• Original: J:180201 Liu C, et al., Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov;130(5):623-32
• All: 2 reference(s)