Del(16Tiam1-Kcnj6)7Yey
Targeted Allele Detail

Summary

• Symbol: Del(16Tiam1-Kcnj6)7Yey
• Name: deletion, Chr 16, Y Eugene Yu 7
• MGI ID: MGI:5305766
• Synonyms: Df(16)2Yey, Df(16Tiam1-Kcnj6)7Yey
• Gene: Del(16Tiam1-Kcnj6)7Yey Location: Chr16:89583999-94798555 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180201
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(16Tiam1-Kcnj6)7Yey involves 110 genes/genome features (Gm22344, Gm22745, Gm22933 ...) View all
• Mutation details: ES cells were targeted twice with MICER vectors inserting 403 kb upstream of the Tiam1 gene and 155 kb downstream of Kcnj6. Transient transfection using a cre-expression vector resulted in recombination between the two targeted sites creating a duplication/deficiency allele pair. (J:180201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16Tiam1-Kcnj6)7Yey Mutation: 1 strain or line available

References

• Original: J:180201 Liu C, et al., Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov;130(5):623-32
• All: 1 reference(s)