Lgals12^tm1Ftl
Targeted Allele Detail

Summary

• Symbol: Lgals12^tm1Ftl
• Name: lectin, galactose binding, soluble 12; targeted mutation 1, Fu-Tong Liu
• MGI ID: MGI:5305940
• Gene: Lgals12 Location: Chr19:7574025-7584558 bp, - strand Genetic Position: Chr19, 5.33 cM
• Alliance: Lgals12^tm1Ftl page

Smaller adipocytes in Lgals12^tm1Ftl/Lgals12^tm1Ftl mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180097
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 3 through 9. Western blot analysis confirmed the absence of protein expression in epididymal adipose tissue. (J:180097)

Generation of the Lgals12^tm1Ftl allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgals12 Mutation: 25 strains or lines available

References

• Original: J:180097 Yang RY, et al., Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18696-701
• All: 2 reference(s)