Agt^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Agt^tm1.1Itl
• Name: angiotensinogen; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5305952
• Synonyms: Agt^fl
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178836
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT and loxP flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination deleted the neo cassette leaving exon 2 floxed. (J:178836)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 35 strains or lines available

References

• Original: J:178836 Yiannikouris F, et al., Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R244-51
• All: 10 reference(s)