Neil3^tm1Bjor
Targeted Allele Detail

Summary

• Symbol: Neil3^tm1Bjor
• Name: nei like 3 (E. coli); targeted mutation 1, Magnar Bjoras
• MGI ID: MGI:5306033
• Gene: Neil3 Location: Chr8:54039902-54092100 bp, - strand Genetic Position: Chr8, 29.14 cM
• Alliance: Neil3^tm1Bjor page

Reduced neuronal regeneration after perinatal hypoxic-ischemia in Neil3^tm1Bjor/Neil3^tm1Bjor mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180177
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 3 through 5, coding the H2TH DNA-binding domain. RT-PCR confirmed the absence of transcript expression. (J:180177)

Generation of the Neil3^tm1Bjor allele

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neil3 Mutation: 26 strains or lines available

References

• Original: J:180177 Sejersted Y, et al., Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18802-7
• All: 8 reference(s)